R/somatic_hypermutation.R
repSomaticHypermutation.RdThis function aligns V and J genes from the germline in each cluster with corresponding genes in each clonotype, saves the alignments for purpose of visualization, and calculates number of mutations for each clonotype.
repSomaticHypermutation(.data, .threads, .nofail)The data to be processed: an output of repClonalFamily(); variants with one sample and list of samples are both supported.
Number of threads to use.
Will return NA instead of stopping if Clustal W is not installed. Used to avoid raising errors in examples on computers where Clustal W is not installed.
Dataframe or list of dataframes (if input is a list with multiple samples). The dataframe has all the columns from repClonalFamily() output dataframe, with Sequence column unnested: the resulting dataframe has one line per clonotype. Clone.ID column contains original IDs for clonotypes, and can be used as dataframe key. New columns are added: * Germline.Alignment.V: contains V gene alignment of current clonotype with the germline * Germline.Alignment.J: contains J gene alignment of current clonotype with the germline * Substitutions: contains number of substitutions in the alignment (summary for V and J) * Insertions: contains number of insertions in the clonotype relative to germline (summary for V and J) * Deletions: contains number of deletions in the clonotype relative to germline (summary for V and J) * Mutations: contains total number of mutations in the alignment (summary for V and J)
data(bcrdata)
bcr_data <- bcrdata$data
bcr_data %>%
seqCluster(seqDist(bcr_data), .fixed_threshold = 3) %>%
repGermline(.threads = 1) %>%
repAlignLineage(.min_lineage_sequences = 2, .align_threads = 2, .nofail = TRUE) %>%
repClonalFamily(.threads = 1, .nofail = TRUE) %>%
repSomaticHypermutation(.threads = 1, .nofail = TRUE)
#> Warning: Genes or alleles IGHV4-55 from sample full_clones not found in the reference and will be dropped!
#> Probably, species argument is wrong (current value: HomoSapiens) or the data contains non-BCR genes.
#> $full_clones
#> Cluster
#> 1 IGHV4-61/IGHJ4_length_45_cluster_1
#> 2 IGHV4-61/IGHJ4_length_45_cluster_1
#> 3 IGHV4-61/IGHJ4_length_63_cluster_1
#> 4 IGHV4-61/IGHJ4_length_63_cluster_1
#> 5 IGHV5-51/IGHJ4_length_60_cluster_1
#> 6 IGHV5-51/IGHJ4_length_60_cluster_1
#> 7 IGHV5-51/IGHJ5_length_45_cluster_1
#> 8 IGHV5-51/IGHJ5_length_45_cluster_1
#> Germline.Input
#> 1 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 2 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 3 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 4 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 5 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 6 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 7 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 8 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> Germline.Output
#> 1 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 2 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 3 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 4 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 5 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 6 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 7 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 8 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> Common.Ancestor
#> 1 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCCATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACRSCACTCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 2 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCCATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACRSCACTCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 3 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACWAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 4 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACWAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 5 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTRAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAASCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 6 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTRAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAASCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 7 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGDTGGGGABCATCTATCCTCGTGACTCTGATACCAGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATVTATTACTGTRCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 8 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGDTGGGGABCATCTATCCTCGTGACTCTGATACCAGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATVTATTACTGTRCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> Trunk.Length
#> 1 7
#> 2 7
#> 3 8
#> 4 8
#> 5 6
#> 6 6
#> 7 6
#> 8 6
#> Tree
#> 1 4, 4, 4, 1, 2, 3, 0.02747, 0.03297, 0.01923, 1, ID_643, ID_42, Germline
#> 2 4, 4, 4, 1, 2, 3, 0.02747, 0.03297, 0.01923, 1, ID_643, ID_42, Germline
#> 3 4, 4, 4, 1, 2, 3, 0.0144, 0.00131, 0.02094, 1, ID_123, ID_119, Germline
#> 4 4, 4, 4, 1, 2, 3, 0.0144, 0.00131, 0.02094, 1, ID_123, ID_119, Germline
#> 5 4, 4, 4, 1, 2, 3, 0.00798, 0.00266, 0.01596, 1, ID_792, ID_416, Germline
#> 6 4, 4, 4, 1, 2, 3, 0.00798, 0.00266, 0.01596, 1, ID_792, ID_416, Germline
#> 7 4, 4, 4, 1, 2, 3, 0.03186, 0.04017, 0.01385, 1, ID_987, ID_283, Germline
#> 8 4, 4, 4, 1, 2, 3, 0.03186, 0.04017, 0.01385, 1, ID_987, ID_283, Germline
#> TreeStats
#> 1 CommonAncestor_1, ID_643, ID_42, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 301, 26, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 7, 9, 11, 0, 7, 5, 8, 0, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCCATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACRSCACTCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGATATATTCATTACAGTGGGAACTCCTTCTACAACCCCTCCCTCAAAAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAGGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACGCCACTCCCTTTGACTACTGGGGCCCGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATGTCCATCACAGTGGGAGCACCAATTACAATCCCTCCCTCAAGCGTCGAGTCACCATGTCAGTAGACACGGCCAGGAAGCAGTTGTCCCTGAAATTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACAGCACTCCCTTTGACTACTGGGGCCAGGGAGCCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 2 CommonAncestor_1, ID_643, ID_42, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 301, 26, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 7, 9, 11, 0, 7, 5, 8, 0, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCCATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACRSCACTCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGATATATTCATTACAGTGGGAACTCCTTCTACAACCCCTCCCTCAAAAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAGGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACGCCACTCCCTTTGACTACTGGGGCCCGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATGTCCATCACAGTGGGAGCACCAATTACAATCCCTCCCTCAAGCGTCGAGTCACCATGTCAGTAGACACGGCCAGGAAGCAGTTGTCCCTGAAATTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACAGCACTCCCTTTGACTACTGGGGCCAGGGAGCCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 3 CommonAncestor_1, ID_123, ID_119, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 53, 290, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 8, 5, 0, 0, 7, 4, 0, 0, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACWAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGAATATCTATTACAGTGGGACTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCCTTAGACACGTCCAAGAACCAGTTCTCCCTGACCCTGAGGTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACAAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACTAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 4 CommonAncestor_1, ID_123, ID_119, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 53, 290, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 8, 5, 0, 0, 7, 4, 0, 0, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACWAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGAATATCTATTACAGTGGGACTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCCTTAGACACGTCCAAGAACCAGTTCTCCCTGACCCTGAGGTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACAAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACTAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 5 CommonAncestor_1, ID_792, ID_416, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 777, 21, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 6, 2, 0, 0, 7, 1, 0, 0, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTRAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAASCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGAATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCAGCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTAAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAACCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTGAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAAGCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 6 CommonAncestor_1, ID_792, ID_416, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 777, 21, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 6, 2, 0, 0, 7, 1, 0, 0, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTRAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAASCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGAATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCAGCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTAAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAACCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTGAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAAGCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 7 CommonAncestor_1, ID_987, ID_283, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 57, 184, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 6, 12, 15, 0, 6, 6, 9, 0, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGDTGGGGABCATCTATCCTCGTGACTCTGATACCAGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATVTATTACTGTRCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGTTGGGGAGCATCTACCCTCGTGACTCTGACACTAGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCCTCAGTACCGCCTACTTGCAGTGGAACAGCCTGCAGGCCTCGGACACCGCCATCTACTACTGTGCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGAAAAGGCCTGGAGTGGGTGGGATCGATCTATCCTCGTGACTCTGATATCAGATACAATCCGTCCTTCCAAGGCCAAGTCACCATCTCAGCCGACAGGTCCACCACCACCGCCTACCTGCAGTGGAGCAGTCTGAAGGCCTCGGACACCGCCATATATTACTGTACGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAGCCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> 8 CommonAncestor_1, ID_987, ID_283, Germline, CommonAncestor, Clonotype, Clonotype, Germline, 1, 57, 184, 1, Germline, CommonAncestor_1, CommonAncestor_1, NA, 6, 12, 15, 0, 6, 6, 9, 0, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGDTGGGGABCATCTATCCTCGTGACTCTGATACCAGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATVTATTACTGTRCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGTTGGGGAGCATCTACCCTCGTGACTCTGACACTAGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCCTCAGTACCGCCTACTTGCAGTGGAACAGCCTGCAGGCCTCGGACACCGCCATCTACTACTGTGCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGAAAAGGCCTGGAGTGGGTGGGATCGATCTATCCTCGTGACTCTGATATCAGATACAATCCGTCCTTCCAAGGCCAAGTCACCATCTCAGCCGACAGGTCCACCACCACCGCCTACCTGCAGTGGAGCAGTCTGAAGGCCTCGGACACCGCCATATATTACTGTACGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAGCCCTGGTCACCGTCTCCTCAG, GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAAGGAACCCTGGTCACCGTCTCCTCAG
#> Sequence
#> 1 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATGTCCATCACAGTGGGAGCACCAATTACAATCCCTCCCTCAAGCGTCGAGTCACCATGTCAGTAGACACGGCCAGGAAGCAGTTGTCCCTGAAATTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACAGCACTCCCTTTGACTACTGGGGCCAGGGAGCCCTGGTCACCGTCTCCTCAG
#> 2 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGATATATTCATTACAGTGGGAACTCCTTCTACAACCCCTCCCTCAAAAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAGGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTCTGTGCGAGAGGCGCCGGGGACTACGCCACTCCCTTTGACTACTGGGGCCCGGGAACCCTGGTCACCGTCTCCTCAG
#> 3 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACTAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 4 CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGAATATCTATTACAGTGGGACTACCAACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCCTTAGACACGTCCAAGAACCAGTTCTCCCTGACCCTGAGGTCTGTGACCGCTGCGGACACGGCCGTGTATTTTTGTGCGAGAGATCATCACAGTTTCTATGATACAAGTGGTTATTATCCCTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 5 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTGAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAAGCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 6 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGAATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGACCAGGTCAGCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGTAAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAACCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 7 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGAAAAGGCCTGGAGTGGGTGGGATCGATCTATCCTCGTGACTCTGATATCAGATACAATCCGTCCTTCCAAGGCCAAGTCACCATCTCAGCCGACAGGTCCACCACCACCGCCTACCTGCAGTGGAGCAGTCTGAAGGCCTCGGACACCGCCATATATTACTGTACGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAGCCCTGGTCACCGTCTCCTCAG
#> 8 GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGTTGGGGAGCATCTACCCTCGTGACTCTGACACTAGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCCTCAGTACCGCCTACTTGCAGTGGAACAGCCTGCAGGCCTCGGACACCGCCATCTACTACTGTGCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> Clone.ID Clones V.allele J.allele CDR1.nt
#> 1 42 26 IGHV4-61*01 IGHJ4*01 ggtggctccgtcagcagtggtggttactac
#> 2 643 301 IGHV4-61*01 IGHJ4*01 ggtggctccgtcagcagtggtggttactac
#> 3 119 290 IGHV4-61*01 IGHJ4*01 ggtggctccgtcagcagtggtggttactac
#> 4 123 53 IGHV4-61*01 IGHJ4*01 ggtggctccgtcagcagtggtggttactac
#> 5 416 21 IGHV5-51*01 IGHJ4*01 ggatacagctttaccagctactgg
#> 6 792 777 IGHV5-51*01 IGHJ4*01 ggatacagctttaccagctactgg
#> 7 283 184 IGHV5-51*01 IGHJ5*01 ggatacagctttaccagctactgg
#> 8 987 57 IGHV5-51*01 IGHJ5*01 ggatacagctttaccagctactgg
#> CDR2.nt
#> 1 GTCCATCACAGTGGGAGCACC
#> 2 ATTCATTACAGTGGGAACTCC
#> 3 ATCTATTACAGTGGGAGTACC
#> 4 ATCTATTACAGTGGGACTACC
#> 5 ATCTATCCTGGTGACTCTGATACC
#> 6 ATCTATCCTGGTGACTCTGATACC
#> 7 ATCTATCCTCGTGACTCTGATATC
#> 8 ATCTACCCTCGTGACTCTGACACT
#> CDR3.nt
#> 1 TGTGCGAGAGGCGCCGGGGACTACAGCACTCCCTTTGACTACTGG
#> 2 TGTGCGAGAGGCGCCGGGGACTACGCCACTCCCTTTGACTACTGG
#> 3 TGTGCGAGAGATCATCACAGTTTCTATGATACTAGTGGTTATTATCCCTACTTTGACTACTGG
#> 4 TGTGCGAGAGATCATCACAGTTTCTATGATACAAGTGGTTATTATCCCTACTTTGACTACTGG
#> 5 TGTGTGAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAAGCTTTGACTACTGG
#> 6 TGTGTAAGACACTCTGGTAAGATAGAATCATCTGTGGGCCCCAGAACCTTTGACTACTGG
#> 7 TGTACGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGG
#> 8 TGTGCGAGACAACACCCTTTAGATAGTCGTGTCTGGTACACTTGG
#> FR1.nt
#> 1 caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctcacctgcactgtctct
#> 2 caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctcacctgcactgtctct
#> 3 caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctcacctgcactgtctct
#> 4 caggtgcagctgcaggagtcgggcccaggactggtgaagccttcggagaccctgtccctcacctgcactgtctct
#> 5 gaggtgcagctggtgcagtctggagcagaggtgaaaaagcccggggagtctctgaagatctcctgtaagggttct
#> 6 gaggtgcagctggtgcagtctggagcagaggtgaaaaagcccggggagtctctgaagatctcctgtaagggttct
#> 7 gaggtgcagctggtgcagtctggagcagaggtgaaaaagcccggggagtctctgaagatctcctgtaagggttct
#> 8 gaggtgcagctggtgcagtctggagcagaggtgaaaaagcccggggagtctctgaagatctcctgtaagggttct
#> FR2.nt
#> 1 tggagctggatccggcagCCCCCAGGGAAGGGACTGGAGTGGATTGGGTAT
#> 2 tggagctggatccggcagCCCCCAGGGAAGGGACTGGAGTGGATTGGATAT
#> 3 tggagctggatccggcagcccccagggaagggactgGAGTGGATTGGGTAT
#> 4 tggagctggatccggcagcccccagggaagggactgGAGTGGATTGGGAAT
#> 5 atcggctgggtgcgccagatgcccgggaaaggcctgGAGTGGATGGGGATC
#> 6 atcggctgggtgcgccagatgcccgggaaaggcctgGAGTGGATGGGAATC
#> 7 atcggctgggtgcgccagatgCCCGGAAAAGGCCTGGAGTGGGTGGGATCG
#> 8 atcggctgggtgcgccagatgCCCGGGAAAGGCCTGGAGTGGTTGGGGAGC
#> FR3.nt
#> 1 AATTACAATCCCTCCCTCAAGCGTCGAGTCACCATGTCAGTAGACACGGCCAGGAAGCAGTTGTCCCTGAAATTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTC
#> 2 TTCTACAACCCCTCCCTCAAAAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAGGTTGACCTCTGTGACCGCTGCGGACACGGCCGTGTATTTC
#> 3 AACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCATTAGACACGTCCAAGAACCAGTTCTCCCTGAACCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTTT
#> 4 AACTACAACCCCTCCCTCAAGAGTCGAGTCAGCATATCCTTAGACACGTCCAAGAACCAGTTCTCCCTGACCCTGAGGTCTGTGACCGCTGCGGACACGGCCGTGTATTTT
#> 5 AGATACAGCCCGTCCTTCCAAGACCAGGTCACCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTAC
#> 6 AGATACAGCCCGTCCTTCCAAGACCAGGTCAGCATGTCAGTCGGCAAGTCCATCGGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTAC
#> 7 AGATACAATCCGTCCTTCCAAGGCCAAGTCACCATCTCAGCCGACAGGTCCACCACCACCGCCTACCTGCAGTGGAGCAGTCTGAAGGCCTCGGACACCGCCATATATTAC
#> 8 AGATACAGTCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCCTCAGTACCGCCTACTTGCAGTGGAACAGCCTGCAGGCCTCGGACACCGCCATCTACTAC
#> FR4.nt
#> 1 GGCCAGGGAGCCCTGGTCACCGTCTCCTCAG
#> 2 GGCCCGGGAACCCTGGTCACCGTCTCCTCAG
#> 3 GGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 4 GGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 5 GGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 6 GGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> 7 GGCCAGGGAGCCCTGGTCACCGTCTCCTCAG
#> 8 GGCCAGGGAACCCTGGTCACCGTCTCCTCAG
#> V.aa
#> 1 QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGGYYWSWIRQPPGKGLEWIGYVHHSGSTNYNPSLKRRVTMSVDTARKQLSLKLTSVTAADTAVYF
#> 2 QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGGYYWSWIRQPPGKGLEWIGYIHYSGNSFYNPSLKSRVTMSVDTSKNQFSLRLTSVTAADTAVYF
#> 3 QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGGYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVSISLDTSKNQFSLNLSSVTAADTAVYF
#> 4 QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGGYYWSWIRQPPGKGLEWIGNIYYSGTTNYNPSLKSRVSISLDTSKNQFSLTLRSVTAADTAVYF
#> 5 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIIYPGDSDTRYSPSFQDQVTMSVGKSIGTAYLQWSSLKASDTAMYY
#> 6 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIIYPGDSDTRYSPSFQDQVSMSVGKSIGTAYLQWSSLKASDTAMYY
#> 7 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWVGSIYPRDSDIRYNPSFQGQVTISADRSTTTAYLQWSSLKASDTAIYY
#> 8 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWLGSIYPRDSDTRYSPSFQGQVTISADKSLSTAYLQWNSLQASDTAIYY
#> J.aa
#> 1 GQGALV~SPSPQ
#> 2 GPGTLV~SPSPQ
#> 3 GQGTLV~SPSPQ
#> 4 GQGTLV~SPSPQ
#> 5 GQGTLV~SPSPQ
#> 6 GQGTLV~SPSPQ
#> 7 GQGALV~SPSPQ
#> 8 GQGTLV~SPSPQ
#> Germline.Alignment.V
#> 1 c, c, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, c, c, a, a, g, g, g, g, a, a, g, g, t, t, c, c, g, g, g, g, g, g, c, c, c, c, c, c, a, a, g, g, g, g, a, a, c, c, t, t, g, g, g, g, t, t, g, g, a, a, a, a, g, g, c, c, c, c, t, t, t, t, c, c, g, g, g, g, a, a, g, g, a, a, c, c, c, c, c, c, t, t, g, g, t, t, c, c, c, c, c, c, t, t, c, c, a, a, c, c, c, c, t, t, g, g, c, c, a, a, c, c, t, t, g, g, t, t, c, c, t, t, c, c, t, t, g, g, g, g, t, t, g, g, g, g, c, c, t, t, c, c, c, c, g, g, t, t, c, c, a, a, g, g, c, c, a, a, g, g, t, t, g, g, g, g, t, t, a, g, g, g, t, t, t, t, a, a, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, g, g, c, c, t, t, g, g, g, g, a, a, t, t, c, c, c, c, g, g, g, g, c, c, a, a, g, g, c, c, c, c, c, c, c, c, c, c, a, a, g, g, g, g, g, g, a, a, a, a, g, g, g, g, g, g, a, a, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, a, t, t, t, t, g, g, g, g, g, g, t, t, a, a, t, t, a, g, t, t, c, c, t, c, a, a, t, t, t, c, a, a, c, c, a, a, g, g, t, t, g, g, g, g, g, g, a, a, g, g, c, c, a, a, c, c, c, c, a, a, a, a, c, t, t, t, a, a, c, c, a, a, a, a, c, t, c, c, c, c, c, c, t, t, c, c, c, c, c, c, t, t, c, c, a, a, a, a, g, g, a, c, g, g, t, t, c, c, g, g, a, a, g, g, t, t, c, c, a, a, c, c, c, c, a, a, t, t, a, g, t, t, c, c, a, a, g, g, t, t, a, a, g, g, a, a, c, c, a, a, c, c, g, g, t, g, c, c, c, c, a, a, a, g, g, g, a, a, a, a, c, g, c, c, a, a, g, g, t, t, t, t, c, g, t, t, c, c, c, c, c, c, t, t, g, g, a, a, a, a, g, a, c, t, t, t, g, g, a, a, g, c, c, c, t, t, c, c, t, t, g, g, t, t, g, g, a, a, c, c, c, c, g, g, c, c, t, t, g, g, c, c, g, g, g, g, a, a, c, c, a, a, c, c, g, g, g, g, c, c, c, c, g, g, t, t, g, g, t, t, a, a, t, t, t, t, a, t, c, c
#> 2 c, c, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, c, c, a, a, g, g, g, g, a, a, g, g, t, t, c, c, g, g, g, g, g, g, c, c, c, c, c, c, a, a, g, g, g, g, a, a, c, c, t, t, g, g, g, g, t, t, g, g, a, a, a, a, g, g, c, c, c, c, t, t, t, t, c, c, g, g, g, g, a, a, g, g, a, a, c, c, c, c, c, c, t, t, g, g, t, t, c, c, c, c, c, c, t, t, c, c, a, a, c, c, c, c, t, t, g, g, c, c, a, a, c, c, t, t, g, g, t, t, c, c, t, t, c, c, t, t, g, g, g, g, t, t, g, g, g, g, c, c, t, t, c, c, c, c, g, g, t, t, c, c, a, a, g, g, c, c, a, a, g, g, t, t, g, g, g, g, t, t, a, g, g, g, t, t, t, t, a, a, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, g, g, c, c, t, t, g, g, g, g, a, a, t, t, c, c, c, c, g, g, g, g, c, c, a, a, g, g, c, c, c, c, c, c, c, c, c, c, a, a, g, g, g, g, g, g, a, a, a, a, g, g, g, g, g, g, a, a, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, a, t, t, t, t, g, g, g, g, g, a, t, t, a, a, t, t, a, a, t, t, c, t, t, c, a, a, t, t, t, t, a, a, c, c, a, a, g, g, t, t, g, g, g, g, g, g, a, a, g, a, c, c, a, t, c, c, c, c, a, t, a, t, c, c, t, t, a, a, c, c, a, a, a, a, c, c, c, c, c, c, c, c, t, t, c, c, c, c, c, c, t, t, c, c, a, a, a, a, g, a, a, a, g, g, t, t, c, c, g, g, a, a, g, g, t, t, c, c, a, a, c, c, c, c, a, a, t, t, a, g, t, t, c, c, a, a, g, g, t, t, a, a, g, g, a, a, c, c, a, a, c, c, g, g, t, t, c, c, c, c, a, a, a, a, g, g, a, a, a, a, c, c, c, c, a, a, g, g, t, t, t, t, c, c, t, t, c, c, c, c, c, c, t, t, g, g, a, a, a, g, g, g, c, t, t, t, g, g, a, a, g, c, c, c, t, t, c, c, t, t, g, g, t, t, g, g, a, a, c, c, c, c, g, g, c, c, t, t, g, g, c, c, g, g, g, g, a, a, c, c, a, a, c, c, g, g, g, g, c, c, c, c, g, g, t, t, g, g, t, t, a, a, t, t, t, t, a, t, c, c
#> 3 c, c, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, c, c, a, a, g, g, g, g, a, a, g, g, t, t, c, c, g, g, g, g, g, g, c, c, c, c, c, c, a, a, g, g, g, g, a, a, c, c, t, t, g, g, g, g, t, t, g, g, a, a, a, a, g, g, c, c, c, c, t, t, t, t, c, c, g, g, g, g, a, a, g, g, a, a, c, c, c, c, c, c, t, t, g, g, t, t, c, c, c, c, c, c, t, t, c, c, a, a, c, c, c, c, t, t, g, g, c, c, a, a, c, c, t, t, g, g, t, t, c, c, t, t, c, c, t, t, g, g, g, g, t, t, g, g, g, g, c, c, t, t, c, c, c, c, g, g, t, t, c, c, a, a, g, g, c, c, a, a, g, g, t, t, g, g, g, g, t, t, a, g, g, g, t, t, t, t, a, a, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, g, g, c, c, t, t, g, g, g, g, a, a, t, t, c, c, c, c, g, g, g, g, c, c, a, a, g, g, c, c, c, c, c, c, c, c, c, c, a, a, g, g, g, g, g, g, a, a, a, a, g, g, g, g, g, g, a, a, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, a, t, t, t, t, g, g, g, g, g, g, t, t, a, a, t, t, a, a, t, t, c, c, t, t, a, a, t, t, t, t, a, a, c, c, a, a, g, g, t, t, g, g, g, g, g, g, a, a, g, g, c, t, a, a, c, c, c, c, a, a, a, a, c, c, t, t, a, a, c, c, a, a, a, a, c, c, c, c, c, c, c, c, t, t, c, c, c, c, c, c, t, t, c, c, a, a, a, a, g, g, a, a, g, g, t, t, c, c, g, g, a, a, g, g, t, t, c, c, a, a, c, g, c, c, a, a, t, t, a, a, t, t, c, c, a, a, g, t, t, t, a, a, g, g, a, a, c, c, a, a, c, c, g, g, t, t, c, c, c, c, a, a, a, a, g, g, a, a, a, a, c, c, c, c, a, a, g, g, t, t, t, t, c, c, t, t, c, c, c, c, c, c, t, t, g, g, a, a, a, a, g, c, c, c, t, t, g, g, a, a, g, g, c, c, t, t, c, c, t, t, g, g, t, t, g, g, a, a, c, c, c, c, g, g, c, c, t, t, g, g, c, c, g, g, g, g, a, a, c, c, a, a, c, c, g, g, g, g, c, c, c, c, g, g, t, t, g, g, t, t, a, a, t, t, t, t, a, t, c, t
#> 4 c, c, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, c, c, a, a, g, g, g, g, a, a, g, g, t, t, c, c, g, g, g, g, g, g, c, c, c, c, c, c, a, a, g, g, g, g, a, a, c, c, t, t, g, g, g, g, t, t, g, g, a, a, a, a, g, g, c, c, c, c, t, t, t, t, c, c, g, g, g, g, a, a, g, g, a, a, c, c, c, c, c, c, t, t, g, g, t, t, c, c, c, c, c, c, t, t, c, c, a, a, c, c, c, c, t, t, g, g, c, c, a, a, c, c, t, t, g, g, t, t, c, c, t, t, c, c, t, t, g, g, g, g, t, t, g, g, g, g, c, c, t, t, c, c, c, c, g, g, t, t, c, c, a, a, g, g, c, c, a, a, g, g, t, t, g, g, g, g, t, t, a, g, g, g, t, t, t, t, a, a, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, g, g, c, c, t, t, g, g, g, g, a, a, t, t, c, c, c, c, g, g, g, g, c, c, a, a, g, g, c, c, c, c, c, c, c, c, c, c, a, a, g, g, g, g, g, g, a, a, a, a, g, g, g, g, g, g, a, a, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, a, t, t, t, t, g, g, g, g, g, g, t, a, a, a, t, t, a, a, t, t, c, c, t, t, a, a, t, t, t, t, a, a, c, c, a, a, g, g, t, t, g, g, g, g, g, g, a, a, g, c, c, t, a, a, c, c, c, c, a, a, a, a, c, c, t, t, a, a, c, c, a, a, a, a, c, c, c, c, c, c, c, c, t, t, c, c, c, c, c, c, t, t, c, c, a, a, a, a, g, g, a, a, g, g, t, t, c, c, g, g, a, a, g, g, t, t, c, c, a, a, c, g, c, c, a, a, t, t, a, a, t, t, c, c, a, c, g, t, t, t, a, a, g, g, a, a, c, c, a, a, c, c, g, g, t, t, c, c, c, c, a, a, a, a, g, g, a, a, a, a, c, c, c, c, a, a, g, g, t, t, t, t, c, c, t, t, c, c, c, c, c, c, t, t, g, g, a, a, a, c, g, c, c, c, t, t, g, g, a, a, g, g, c, g, t, t, c, c, t, t, g, g, t, t, g, g, a, a, c, c, c, c, g, g, c, c, t, t, g, g, c, c, g, g, g, g, a, a, c, c, a, a, c, c, g, g, g, g, c, c, c, c, g, g, t, t, g, g, t, t, a, a, t, t, t, t, a, t, c, t
#> 5 g, g, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, g, g, t, t, g, g, c, c, a, a, g, g, t, t, c, c, t, t, g, g, g, g, a, a, g, g, c, c, a, a, g, g, a, a, g, g, g, g, t, t, g, g, a, a, a, a, a, a, a, a, a, a, g, g, c, c, c, c, c, c, g, g, g, g, g, g, g, g, a, a, g, g, t, t, c, c, t, t, c, c, t, t, g, g, a, a, a, a, g, g, a, a, t, t, c, c, t, t, c, c, c, c, t, t, g, g, t, t, a, a, a, a, g, g, g, g, g, g, t, t, t, t, c, c, t, t, g, g, g, g, a, a, t, t, a, a, c, c, a, a, g, g, c, c, t, t, t, t, t, t, a, a, c, c, c, c, a, a, g, g, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, t, t, c, c, g, g, g, g, c, c, t, t, g, g, g, g, g, g, t, t, g, g, c, c, g, g, c, c, c, c, a, a, g, g, a, a, t, t, g, g, c, c, c, c, c, c, g, g, g, g, g, g, a, a, a, a, a, a, g, g, g, g, c, c, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, a, t, t, g, g, g, g, g, g, g, g, a, a, t, t, c, c, a, a, t, t, c, c, t, t, a, a, t, t, c, c, c, c, t, t, g, g, g, g, t, t, g, g, a, a, c, c, t, t, c, c, t, t, g, g, a, a, t, t, a, a, c, c, c, c, a, a, g, g, a, a, t, t, a, a, c, c, a, a, g, g, c, c, c, c, c, c, g, g, t, t, c, c, c, c, t, t, t, t, c, c, c, c, a, a, a, a, g, g, g, a, c, c, c, c, a, a, g, g, g, g, t, t, c, c, a, a, c, c, c, c, a, a, t, t, c, g, t, t, c, c, a, a, g, g, c, t, c, c, g, g, a, g, c, c, a, a, a, a, g, g, t, t, c, c, c, c, a, a, t, t, c, c, a, g, g, g, c, c, a, a, c, c, c, c, g, g, c, c, c, c, t, t, a, a, c, c, c, c, t, t, g, g, c, c, a, a, g, g, t, t, g, g, g, g, a, a, g, g, c, c, a, a, g, g, c, c, c, c, t, t, g, g, a, a, a, a, g, g, g, g, c, c, c, c, t, t, c, c, g, g, g, g, a, a, c, c, a, a, c, c, c, c, g, g, c, c, c, c, a, a, t, t, g, g, t, t, a, a, t, t, t, t, a, a, c, c
#> 6 g, g, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, g, g, t, t, g, g, c, c, a, a, g, g, t, t, c, c, t, t, g, g, g, g, a, a, g, g, c, c, a, a, g, g, a, a, g, g, g, g, t, t, g, g, a, a, a, a, a, a, a, a, a, a, g, g, c, c, c, c, c, c, g, g, g, g, g, g, g, g, a, a, g, g, t, t, c, c, t, t, c, c, t, t, g, g, a, a, a, a, g, g, a, a, t, t, c, c, t, t, c, c, c, c, t, t, g, g, t, t, a, a, a, a, g, g, g, g, g, g, t, t, t, t, c, c, t, t, g, g, g, g, a, a, t, t, a, a, c, c, a, a, g, g, c, c, t, t, t, t, t, t, a, a, c, c, c, c, a, a, g, g, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, t, t, c, c, g, g, g, g, c, c, t, t, g, g, g, g, g, g, t, t, g, g, c, c, g, g, c, c, c, c, a, a, g, g, a, a, t, t, g, g, c, c, c, c, c, c, g, g, g, g, g, g, a, a, a, a, a, a, g, g, g, g, c, c, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, a, t, t, g, g, g, g, g, g, g, a, a, a, t, t, c, c, a, a, t, t, c, c, t, t, a, a, t, t, c, c, c, c, t, t, g, g, g, g, t, t, g, g, a, a, c, c, t, t, c, c, t, t, g, g, a, a, t, t, a, a, c, c, c, c, a, a, g, g, a, a, t, t, a, a, c, c, a, a, g, g, c, c, c, c, c, c, g, g, t, t, c, c, c, c, t, t, t, t, c, c, c, c, a, a, a, a, g, g, g, a, c, c, c, c, a, a, g, g, g, g, t, t, c, c, a, a, c, g, c, c, a, a, t, t, c, g, t, t, c, c, a, a, g, g, c, t, c, c, g, g, a, g, c, c, a, a, a, a, g, g, t, t, c, c, c, c, a, a, t, t, c, c, a, g, g, g, c, c, a, a, c, c, c, c, g, g, c, c, c, c, t, t, a, a, c, c, c, c, t, t, g, g, c, c, a, a, g, g, t, t, g, g, g, g, a, a, g, g, c, c, a, a, g, g, c, c, c, c, t, t, g, g, a, a, a, a, g, g, g, g, c, c, c, c, t, t, c, c, g, g, g, g, a, a, c, c, a, a, c, c, c, c, g, g, c, c, c, c, a, a, t, t, g, g, t, t, a, a, t, t, t, t, a, a, c, c
#> 7 g, g, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, g, g, t, t, g, g, c, c, a, a, g, g, t, t, c, c, t, t, g, g, g, g, a, a, g, g, c, c, a, a, g, g, a, a, g, g, g, g, t, t, g, g, a, a, a, a, a, a, a, a, a, a, g, g, c, c, c, c, c, c, g, g, g, g, g, g, g, g, a, a, g, g, t, t, c, c, t, t, c, c, t, t, g, g, a, a, a, a, g, g, a, a, t, t, c, c, t, t, c, c, c, c, t, t, g, g, t, t, a, a, a, a, g, g, g, g, g, g, t, t, t, t, c, c, t, t, g, g, g, g, a, a, t, t, a, a, c, c, a, a, g, g, c, c, t, t, t, t, t, t, a, a, c, c, c, c, a, a, g, g, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, t, t, c, c, g, g, g, g, c, c, t, t, g, g, g, g, g, g, t, t, g, g, c, c, g, g, c, c, c, c, a, a, g, g, a, a, t, t, g, g, c, c, c, c, c, c, g, g, g, g, g, a, a, a, a, a, a, a, g, g, g, g, c, c, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, g, t, t, g, g, g, g, g, g, g, a, a, t, t, c, c, g, a, a, t, t, c, c, t, t, a, a, t, t, c, c, c, c, t, t, g, c, g, g, t, t, g, g, a, a, c, c, t, t, c, c, t, t, g, g, a, a, t, t, a, a, c, t, c, c, a, a, g, g, a, a, t, t, a, a, c, c, a, a, g, a, c, t, c, c, c, c, g, g, t, t, c, c, c, c, t, t, t, t, c, c, c, c, a, a, a, a, g, g, g, g, c, c, c, c, a, a, g, a, g, g, t, t, c, c, a, a, c, c, c, c, a, a, t, t, c, c, t, t, c, c, a, a, g, g, c, c, c, c, g, g, a, a, c, c, a, a, a, g, g, g, t, t, c, c, c, c, a, a, t, c, c, c, a, a, g, c, c, c, a, a, c, c, c, c, g, g, c, c, c, c, t, t, a, a, c, c, c, c, t, t, g, g, c, c, a, a, g, g, t, t, g, g, g, g, a, a, g, g, c, c, a, a, g, g, c, t, c, c, t, t, g, g, a, a, a, a, g, g, g, g, c, c, c, c, t, t, c, c, g, g, g, g, a, a, c, c, a, a, c, c, c, c, g, g, c, c, c, c, a, a, t, t, g, a, t, t, a, a, t, t, t, t, a, a, c, c
#> 8 g, g, a, a, g, g, g, g, t, t, g, g, c, c, a, a, g, g, c, c, t, t, g, g, g, g, t, t, g, g, c, c, a, a, g, g, t, t, c, c, t, t, g, g, g, g, a, a, g, g, c, c, a, a, g, g, a, a, g, g, g, g, t, t, g, g, a, a, a, a, a, a, a, a, a, a, g, g, c, c, c, c, c, c, g, g, g, g, g, g, g, g, a, a, g, g, t, t, c, c, t, t, c, c, t, t, g, g, a, a, a, a, g, g, a, a, t, t, c, c, t, t, c, c, c, c, t, t, g, g, t, t, a, a, a, a, g, g, g, g, g, g, t, t, t, t, c, c, t, t, g, g, g, g, a, a, t, t, a, a, c, c, a, a, g, g, c, c, t, t, t, t, t, t, a, a, c, c, c, c, a, a, g, g, c, c, t, t, a, a, c, c, t, t, g, g, g, g, a, a, t, t, c, c, g, g, g, g, c, c, t, t, g, g, g, g, g, g, t, t, g, g, c, c, g, g, c, c, c, c, a, a, g, g, a, a, t, t, g, g, c, c, c, c, c, c, g, g, g, g, g, g, a, a, a, a, a, a, g, g, g, g, c, c, c, c, t, t, g, g, g, g, a, a, g, g, t, t, g, g, g, g, a, t, t, t, g, g, g, g, g, g, g, g, a, a, t, g, c, c, a, a, t, t, c, c, t, t, a, a, t, c, c, c, c, c, t, t, g, c, g, g, t, t, g, g, a, a, c, c, t, t, c, c, t, t, g, g, a, a, t, c, a, a, c, c, c, t, a, a, g, g, a, a, t, t, a, a, c, c, a, a, g, g, c, t, c, c, c, c, g, g, t, t, c, c, c, c, t, t, t, t, c, c, c, c, a, a, a, a, g, g, g, g, c, c, c, c, a, a, g, g, g, g, t, t, c, c, a, a, c, c, c, c, a, a, t, t, c, c, t, t, c, c, a, a, g, g, c, c, c, c, g, g, a, a, c, c, a, a, a, a, g, g, t, t, c, c, c, c, a, c, t, t, c, c, a, a, g, g, c, t, a, a, c, c, c, c, g, g, c, c, c, c, t, t, a, a, c, c, c, t, t, t, g, g, c, c, a, a, g, g, t, t, g, g, g, g, a, a, g, a, c, c, a, a, g, g, c, c, c, c, t, t, g, g, a, c, a, a, g, g, g, g, c, c, c, c, t, t, c, c, g, g, g, g, a, a, c, c, a, a, c, c, c, c, g, g, c, c, c, c, a, a, t, t, g, c, t, t, a, a, t, c, t, t, a, a, c, c
#> Germline.Alignment.J
#> 1 g, g, g, g, c, c, c, c, a, a, a, g, g, g, g, g, a, a, a, g, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> 2 g, g, g, g, c, c, c, c, a, c, a, g, g, g, g, g, a, a, a, a, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> 3 g, g, g, g, c, c, c, c, a, a, a, g, g, g, g, g, a, a, a, a, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> 4 g, g, g, g, c, c, c, c, a, a, a, g, g, g, g, g, a, a, a, a, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> 5 g, g, g, g, c, c, c, c, a, a, a, g, g, g, g, g, a, a, a, a, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> 6 g, g, g, g, c, c, c, c, a, a, a, g, g, g, g, g, a, a, a, a, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> 7 g, g, g, g, c, c, c, c, a, a, a, g, g, g, g, g, a, a, a, g, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> 8 g, g, g, g, c, c, c, c, a, a, a, g, g, g, g, g, a, a, a, a, c, c, c, c, c, c, t, t, g, g, g, g, t, t, c, c, a, a, c, c, c, c, g, g, t, t, c, c, t, t, c, c, c, c, t, t, c, c, a, a, g, g
#> Substitutions Insertions Deletions Mutations
#> 1 18 0 0 18
#> 2 16 0 0 16
#> 3 8 0 0 8
#> 4 13 0 0 13
#> 5 6 0 0 6
#> 6 8 0 0 8
#> 7 18 0 0 18
#> 8 15 0 0 15
#>